From Holy Thursday evening to Easter Sunday it’s a festive time in Rome. On Good Friday there’s a procession of the Cross from the Colosseum to Capitoline Hill. The highlight will be Sunday though. The Pope leads a Holy Mass in the morning on Saint Peter’s Square and afterwards the Pope delivers the blessing known as the “Urbi et Orbi – to the City and to the World” from the balcony on the façade of Saint Peter’s Basilica.
All public museums will be open on Easter Sunday and Monday. That does not include the Vatican museums and the Sistine Chapel, however, which will be closed on both days. You better make reservations in restaurants in advance on Sunday and Monday. Easter Monday is a public holiday, so transportation is on a holiday schedule that day.